Fig. 1.

AR-V7 cistromes and their regulated transcriptomes are heterogeneous in AR-V7–driven CRPC. (A) A heatmap of differentially expressed genes [false-discovery rate (FDR) < 0.05, fold-change > 2] after AR-V7 silencing. The gene expression [reads per kilobase per million mapped reads (RPKM)] values for each gene were normalized to the standard normal distribution to generate z-scores. The scale bar is shown with the minimum expression value for each gene in blue and the maximum value in red. (B) Venn diagrams show AR-V7 up-regulated and down-regulated genes in 22RV1 and LN95 cells, respectively. (C) Overlap of AR-V7 binding sites between 22RV1 and LN95 cells. (D and E) ChIP-exo raw tags distribution (1-bp resolution) over AREs on the forward (blue, Left) and reverse (red, Right) strands, respectively in 22RV1 cells (D) and LN95 cells (E). The Center panels represent the bound ARE sequences ordered as in the Left and Right.