Table 4.
Triple-negative breast cancers with high copy number variant burden1
| Sample | Gene lesion | PD-1 | PD-L1 | Neoadjuvant |
|---|---|---|---|---|
| TNBC-8 | MSH2F289C | 2 | 4 NT | + |
| TNBC-53 | MLH3−/− | 3 | 3 NT | + |
| TNBC-30 | CHEK2−/− | 1 | 1 NT | – |
| TNBC-31 | BRIP1−/− | 3 | 2 NT | – |
| TNBC-24 | BRCAmut | 4 | 5 T | – |
| TNBC-27 | FBXW7S398F | 2 | 3 NT | + |
| TNBC-29 | PRKDCQ75R | 2 | 4 T | + |
| TNBC-17 | ALKBH5P303Q | 1 | 2 NT | – |
| TNBC-36 | DCLRE1C656_671del16 | 3 | 4 T/NT | + |
| TNBC-54 | TBD | 2 | 2 T/NT | + |
| TNBC-51 | TBD | 1 | 0 | + |
| TNBC-23 | TBD | 3 | 4 T/NT | – |
1>50 intrachromosomal copy number variants
Abbreviations: NT non-tumor cells, T tumor cells, TBD to be determined, TNBC triple-negative breast cancer