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. 2018 Jul 11;18:112. doi: 10.1186/s12876-018-0842-7

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Heatmap analysis, summary of pathway effect, compound impact on pathway and Spearman correlation. a Heatmap analysis indicated that TCA, TCDCA, TUDCA, GCA, UDCA, CDCA, CA, TLCA, TDCA, HDCA and LCA were increased in liver cirrhosis as compared with healthy controls. b Pathway analysis showed that primary bile acid biosynthesis was increased in liver cirrhosis. 1: bile acid biosynthesis. 2: taurine and hypotaurine metabolism. c Compound impact analysis implied that TCA impacted most in the increased primary bile acid biosynthesis in liver cirrhosis. d Spearman correlation analysis indicated that concentrations of TCA, GCA and TCDCA were significantly positively correlated with Child-Pugh classification (P < 0.0001). And concentrations of LCA, HDCA, CDCA, UDCA, CA, TLCA, TDCA and TUDCA were not correlated with Child-Pugh classification (P > 0.05)