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. 2018 Jul 11;23:33. doi: 10.1186/s11658-018-0099-8

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — LAMP3 regulated cell apoptosis in osteosarcoma (OS) cells. a and c – Apoptosis assay results showing that the percentage of apoptotic cells increased after inhibition of LAMP3 compared with the control. E – The apoptotic rate significantly decreased when LAMP3 was overexpressed compared with the control cells. b and d – Western blots showing the upregulated expression of cleaved-caspase-3 (b) and TP53 (d) after knockdown of LAMP3 in either OS-732 or U2OS cells. f – Representative example of the downregulated expression of cleaved-caspase-3 and TP53 at the protein level with exogenous LAMP3 expression. *p < 0.05, **p < 0.01, ***p < 0.001, n = 3