Table 5.

Performance of miRNAs and their combinations to predict relapse in patients with early breast cancer

Potential predictors	Cutoff value	Sensitivity (%)	Specificity (%)	AUC (95% CI)	p
Early breast cancer
miR-21	0.98	71.4	63.9	0.685 (0.592–0.777)	< 0.001
miR-23b	1.35	38.8	83.3	0.614 (0.512–0.716)	0.029
miR-190	2.36	75.6	45.2	0.636 (0.534–0.738)	0.013
miR-200b	1.72	51.0	72.3	0.597 (0.498–0.696)	0.063
miR-200c	1.15	75.5	61.0	0.678 (0.586–0.769)	< 0.001
Three miRNAS (miR-21, miR-23b, miR-190)	0.39	80	65.3	0.765 (0.673–0.850)	< 0.001
Lymph nodes and grade	0.29	83	46.7	0.709 (0.614–0.804)	< 0.001
Three miRNAS plus lymph nodes and grade	0.41	89	76.2	0.873 (0.802–0.940)	< 0.001
Late relapse (≥ 5 years)
miR-200c and lymph nodes, grade and ER status	0.42	75	89	0.89 (0.812–0.972)	< 0.001

AUC area under the receiver operating curve, ER estrogen receptor