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. 2018 Jul 11;20:70. doi: 10.1186/s13058-018-0994-y

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Diamond plot comparing –log₁₀ p value × sign of coefficient for the estimated association between 25(OH)D and logit(methylation): subcohort (n = 1270, including 46 breast cancer cases) versus other breast cancer cases (n = 1024). The broken lines show critical values for single (vertical and horizontal grid lines) and Fisher’s combined (diagonal lines) p values, based on χ² tests with 2 (for single) and 4 (for combined) degrees of freedom