Table 3.
CpG sites associated with serum 25(OH)D levels in subcohort (q < 0.10)
| CpG site | Location (Chr:position) | Location type | Gene | Effect estimatea (95% CI) | p value | q value |
|---|---|---|---|---|---|---|
| cg24350360 | 1:225997662b | TSS200 | EPHX1 | −0.04 (−0.06 to −0.03) | 3.4 × 10−8 | 0.01 |
| cg06177555 | 16:29678624 | 3′ UTR | SPN | −0.02 (−0.03 to −0.01) | 9.8 × 10−8 | 0.02 |
| cg13243168 | 17:61915833 | Body | SMARCD2 | −0.02 (−0.03 to −0.01) | 2.9 × 10−7 | 0.04 |
| cg23761815 | 10:73083123 | Body | SLC29A3 | −0.02 (−0.03 to −0.01) | 5.1 × 10−7 | 0.05 |
| cg10401362 | 7:157185402 | Body | DNAJB6 | −0.02 (−0.03 to −0.01) | 1.0 × 10−6 | 0.09 |
CI confidence interval, TSS200 within 200 basepairs upstream of the transcription start site, UTR untranslated region
aEstimated change in methylation (logit(β)) per 10 ng/mL change in serum 25-hydroxyvitamin D (25(OH)D)
bIntraclass correlation coefficient < 0.5