Table 2.

Clinical trial outcome measures developed by the Pediatric Rheumatology Collaborative Study Group Leadership in collaboration with other pediatric rheumatology networks

PEDIATRIC RHEUMATIC DISEASE	Outcome measure	Reference
Juvenile Idiopathic Arthritis	Core set of Outcome Measuresa	[35]
	Preliminary Definition of Improvementa	[36]
	Preliminary Flare Criteriaa	[37]
	Provisional criteria for inactive disease & clinical remissiona	[38]
	Macrophage Activation Syndromea	[39]
Systemic Lupus Erythematosus	Disease activity	[40]
	Disease damage	[41]
	Core Set of Outcome Measuresa	[42]
	Provisional Improvement Criteriab	[43]
	Preliminary Flare Criteriab	[44]
	Preliminary Inactive Disease Criteriab	[45]
Juvenile Dermatomyositis	Childhood Myositis Activity Assessment Scalec	[46]
	Core set measures of disease activity and damagea	[42]
	Provisional Criteria for Response to Therapya	[47]

^aDeveloped in collaboration with Pediatric Rheumatology International Trials Organization (PRINTO)

^bDeveloped in collaboration with PRINTO and Childhood Arthritis and Rheumatology Research Alliance (CARRA)

^cDeveloped in collaboration with Juvenile Dermatomyositis Disease Activity Collaborative Study Group (predecessor to International Myositis Assessment and Clinical Studies Group)