Fig. 2.

Effect of 1,25D on serotonin degrading pathway and control mRNAs in U87 glioblastoma cells. P values listed at the top of bars represent statistical significance for comparison between 1,25D-treatment and ethanol vehicle control group in each and all cases. Statistical analyses were performed using ANOVA with a post hoc adjustment of P values via the Dunnett test that compares every mean to a control mean and takes into account the scatter of all the groups. a Expression of SERT in U87 human glioblastoma cells treated with 1,25D. Each mRNA value is the average of seven biological replicates ± std. dev. b Expression of MAO-A in U87 human glioblastoma cells treated with 1,25D. Each mRNA value is the average of 11 biological replicates ± std. dev. c Expression of MAO-B in U87 glioblastoma cells treated with 1,25D. Each mRNA value is the average of 27 biological replicates ± std. dev. d Expression of CYP24A1 in U87 glioblastoma cells treated with 1,25D. Each mRNA value represents the average of seven biological replicates ± std. dev