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. 2018 Jul 11;12:36. doi: 10.1186/s40246-018-0168-0

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Position of the variants with defects in ubiquitin transferase activity, BARD1 binding, and UBE2D1 binding for the first 300 BRCA1 residues. Positions where variations have no or mild impact are shown in green, those with moderate effects in yellow, and those with severe defects in red. The positions with no data are in white. The RING domain is indicated (positions 24 to 65)