Table 2.
Pharmacokinetic parameter | 1.0 mg/kg IV | 1.0 mg/kg SC | 1.0 mg/kg PO |
---|---|---|---|
Cmax (ng/mL) | 988a | 269b | 156b |
Tmax (h) | NA | 0.43a, 0.5–2.0b | 2–3b |
T1/2 (h) | 4.9a | 6.6a |
Notes: The reported bioavailability is 117% after SC administration and 50% after oral administration. The time to peak plasma concentration is reported to range from 26 minutes (label) up to 2 hours.19 Data from
Cerenia (tablets and injectable marketing package insert), Zoetis Inc.16 and
Hickman et al.19
Abbreviations: Cmax, peak plasma concentration; IV, intravenous; PO, per oro; SC, subcutaneous; Tmax, time to Cmax.