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. 2018 Jul 9;12:2111–2128. doi: 10.2147/DDDT.S161944

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© 2018 Parikh et al. This work is published and licensed by Dove Medical Press Limited

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Results of NORT.

Notes: Recognition index in the phase of familiarization (A) and the test phase (B), discrimination index in the test phase (C). ****P<0.0001 (one-way ANOVA, Tukey’s test) (mean±SEM).

Abbreviations: NEF, novel edaravone formulation; NORT, novel objective recognition test; 17 mo WT Ctrl, 17-month-old normal wild-type control mice; 17 mo Tg Ctrl, 17-month-old transgenic sham control mice; 14 mo Tg Ctrl, 14-month-old transgenic mice as a basal control; 17 mo Tg BC, 17-month-old transgenic blank control mice; 17 mo Tg NEF LD, 17-month-old transgenic mice treated with low dose of NEF; 17 mo Tg NEF MD, 17-month-old transgenic mice treated with medium dose of NEF; 17 mo Tg NEF HD, 17-month-old transgenic mice treated with high dose of NEF; 17 mo Tg DNP, 17-month-old transgenic mice treated with high dose of donepezil; SEM, standard error of the mean; ANOVA, analysis of variance.