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. 2018 Jul 9;12:2111–2128. doi: 10.2147/DDDT.S161944

Figure 5.

Figure 5

The performances of Tg mice in MWM test.

Notes: Path length (cm) to the platform (A), swim speed (cm/s) during platform trials and probe test (B), escape latency (s) during platform trials and distance travelled on each day of training (C), number of annulus crossings in probe trial (D), comparison of time spent in target zone (Q3) (first bar) where platform was located compared with the average of all other zones (o.a.) (second bar) (E). *P<0.05 and **P<0.01 (two-way or one-way ANOVA, Tukey’s test) (mean±SEM).

Abbreviations: NEF, novel edaravone formulation; MWM, Morris water maze; 17 mo WT Ctrl, 17-month-old normal wild-type control mice; 17 mo Tg Ctrl, 17-month-old transgenic sham control mice; 14 mo Tg Ctrl, 14-month-old transgenic mice as a basal control; 17 mo Tg BC, 17-month-old transgenic blank control mice; 17 mo Tg NEF LD, 17-month-old transgenic mice treated with low dose of NEF; 17 mo Tg NEF MD, 17-month-old transgenic mice treated with medium dose of NEF; 17 mo Tg NEF HD, 17-month-old transgenic mice treated with high dose of NEF; 17 mo Tg DNP, 17-month-old transgenic mice treated with high dose of donepezil; SEM, standard error of the mean; ANOVA, analysis of variance.