Table 2.
Measurement of food and water consumption and body weight of Tg mice (mean±SD, n=5)
| Parameter | Time | APP/PS1 mice
|
||
|---|---|---|---|---|
| 17 mo Tg Ctrl | 17 mo Tg BC | 17 mo Tg NEF HD | ||
| Food intake (g/d/10 g body weight) | Before addition (14 months)* | 1.34±0.19 | 1.36±0.26 | 1.38±0.25 |
| After addition (14 months)+ | – | 1.33±0.22 | 1.33±0.31 | |
| At 17 months | 1.22±0.31 | 1.24±0.22 | 1.19±0.25 | |
| Water intake (g/d/10 g body weight) | Before addition (14 months)* | 1.42±0.42 | 1.41±0.32 | 1.43±0.32 |
| After addition (14 months)+ | – | 1.48±0.24 | 1.52±0.34 | |
| At 17 months | 1.25±0.20 | 1.27±0.28 | 1.23±0.27 | |
| Body weight (g) | Before addition (14 months)* | 33.13±3.24 | 33.9±4.82 | 32.81±2.59 |
| After addition (14 months)+ | – | 34.6±3.45 | 34.32±2.99 | |
| At 17 months | 34.15±3.13 | 34.24±3.17 | 34.58±3.12 | |
Notes:
*
Before addition of treatment such as blank formulation (17 mo Tg BC) and NEF (17 mo Tg NEF HD).
+
After addition of treatment such as blank formulation (17 mo Tg BC) and NEF (17 mo Tg NEF HD).
Abbreviations: Tg, transgenic mice; 17 mo Tg Ctrl, 17-month-old transgenic sham control mice; 17 mo Tg BC, 17-month-old transgenic blank control mice; 17 mo Tg NEF HD, 17-month-old transgenic mice treated with high dose of NEF; NEF, novel edaravone formulation.