Table 3.
OR with 95% CI for no and one lifetime pregnancy (reference: women with ≥2 pregnancies) by prepregnant lipid quintiles in 4322 women in the Cohort of Norway (1994–2003), analyses stratified by BMI
| Lipid quintiles* in mmol/L | Women with prepregnant BMI<25 | Women with prepregnant BMI≥25 | ||||||||||||
| n | na | nb | N | Nulliparous | One-child mothers OR (95% CI) | P for trend | n | na | nb | N | Nulliparous OR (95% CI) | One-child mothers OR (95% CI) | P for trend | |
| OR (95% CI) | ||||||||||||||
| LDL cholesterol† | 0.84 | 0.44 | ||||||||||||
| <2.42 | 377 | 219 | 69 | 665 | 1.0 (reference) | 1.0 (reference) | 72 | 41 | 11 | 124 | 1.0 (reference) | 1.0 (reference) | ||
| 2.43–2.84 | 343 | 240 | 64 | 647 | 1.1 (0.9 to 1.5) | 0.9 (0.6 to 1.4) | 90 | 68 | 20 | 178 | 1.1 (0.6 to 2.1) | 1.4 (0.6 to 3.3) | ||
| 2.85–3.24 | 341 | 216 | 67 | 624 | 1.0 (0.7 to 1.3) | 0.9 (0.6 to 1.3) | 113 | 109 | 23 | 245 | 1.5 (0.8 to 2.6) | 1.4 (0.6 to 3.3) | ||
| 3.25–3.76 | 315 | 198 | 69 | 582 | 1.0 (0.8 to 1.4) | 1.1 (0.7 to 1.6) | 111 | 152 | 39 | 302 | 1.7 (1.0 to 3.0) | 1.8 (0.8 to 4.0) | ||
| >3.77 | 230 | 187 | 64 | 481 | 1.2 (0.9 to 1.6) | 1.2 (0.8 to 1.8) | 158 | 233 | 57 | 448 | 1.7 (1.0 to 3.0) | 1.8 (0.8 to 3.8) | ||
| Total cholesterol | 0.13 | 0.04 | ||||||||||||
| <4.19 | 359 | 198 | 75 | 632 | 1.0 (reference) | 1.0 (reference) | 73 | 60 | 19 | 152 | 1.0 (reference) | 1.0 (reference) | ||
| 4.20–4.61 | 341 | 231 | 57 | 629 | 1.4 (1.1 to 1.9) | 0.8 (0.5 to 1.2) | 115 | 73 | 17 | 205 | 0.6 (0.3 to 1.0) | 0.7 (0.3 to 1.5) | ||
| 4.62–5.0 | 332 | 191 | 64 | 587 | 1.0 (0.7 to 1.3) | 0.8 (0.5 to 1.2) | 102 | 114 | 27 | 243 | 1.3 (0.8 to 2.2) | 1.2 (0.6 to 2.5) | ||
| 5.1–5.63 | 327 | 244 | 72 | 643 | 1.3 (0.9 to 1.7) | 0.9 (0.6 to 1.4) | 114 | 167 | 37 | 318 | 1.5 (0.9 to 2.5) | 1.2 (0.6 to 2.4) | ||
| >5.64 | 248 | 196 | 66 | 510 | 1.3 (0.9 to 1.7) | 1.0 (0.7 to 1.5) | 143 | 197 | 53 | 393 | 1.2 (0.7 to 2.0) | 1.2 (0.6 to 2.4) | ||
| TG | 0.04 | <0.001 | ||||||||||||
| <0.66 | 363 | 311 | 69 | 743 | 1.0 (reference) | 1.0 (reference) | 66 | 59 | 12 | 137 | 1.0 (reference) | 1.0 (reference) | ||
| 0.67–0.86 | 364 | 248 | 82 | 694 | 0.8 (0.6 to 1.0) | 1.2 (0.5 to 2.8) | 83 | 102 | 18 | 203 | 1.7 (1.0 to 3.0) | 1.2 (0.5 to 2.8) | ||
| 0.87–1.09 | 339 | 208 | 65 | 612 | 0.9 (0.7 to 1.2) | 1.3 (0.7 to 3.8) | 115 | 85 | 23 | 223 | 1.6 (0.9 to 2.8) | 1.7 (0.7 to 3.8) | ||
| 1.10–1.45 | 319 | 156 | 58 | 533 | 0.8 (0.6 to 1.1) | 1.3 (0.9 to 4.8) | 133 | 146 | 30 | 309 | 2.5 (1.5 to 4.4) | 2.1 (0.9 to 4.8) | ||
| >1.46 | 222 | 137 | 59 | 418 | 1.0 (0.7 to 1.4) | 2.0 (1.7 to 7.4) | 149 | 219 | 70 | 438 | 2.8 (1.7 to 4.7) | 3.5 (1.6 to 7.4) | ||
| HDL cholesterol | 0.05 | 0.17 | ||||||||||||
| <1.20 | 198 | 70 | 47 | 315 | 0.9 (0.7 to 1.2) | 1.7 (1.1 to 2.6) | 127 | 191 | 50 | 368 | 1.9 (1.2 to 3.0) | 2.6 (1.3 to 5.3) | ||
| 1.21–1.40 | 189 | 138 | 43 | 370 | 0.9 (0.7 to 1.1) | 1.0 (0.6 to 1.5) | 81 | 122 | 31 | 234 | 1.7 (1.0 to 2.8) | 2.3 (1.1 to 4.9) | ||
| 1.41–1.60 | 475 | 287 | 93 | 855 | 0.8 (0.6 to 1.1) | 1.1 (0.8 to 1.5) | 158 | 143 | 37 | 338 | 1.4 (0.9 to 2.2) | 1.8 (0.9 to 3.6) | ||
| 1.61–1.84 | 358 | 272 | 74 | 704 | 0.7 (0.5 to 1.0) | 1.0 (0.7 to 1.4) | 85 | 82 | 18 | 185 | 1.4 (0.8 to 2.4) | 1.8 (0.8 to 4.0) | ||
| >1.85 | 387 | 293 | 77 | 757 | 1.0 (reference) | 1.0 (reference) | 96 | 73 | 17 | 186 | 1.0 (reference) | 1.0 (reference) | ||
| TG:HDL-c ratio | 0.04 | <0.001 | ||||||||||||
| <0.39 | 374 | 321 | 70 | 765 | 1.0 (reference) | 1.0 (reference) | 67 | 42 | 10 | 119 | 1.0 (reference) | 1.0 (reference) | ||
| 0.40–0.54 | 365 | 245 | 75 | 685 | 0.8 (0.6 to 1.0) | 1.2 (0.8 to 1.7) | 85 | 99 | 17 | 201 | 2.2 (1.2 to 4.0) | 1.9 (0.7 to 4.9) | ||
| 0.55–0.73 | 365 | 213 | 71 | 649 | 0.8 (0.6 to 1.1) | 1.2 (0.8 to 1.8) | 101 | 91 | 22 | 214 | 2.4 (1.3 to 4.3) | 2.2 (0.9 to 5.5) | ||
| 0.74–1.04 | 281 | 172 | 64 | 517 | 0.9 (0.7 to 1.2) | 1.6 (1.1 to 2.4) | 138 | 131 | 33 | 302 | 3.3 (1.9 to 5.9) | 3.1 (1.3 to 7.4) | ||
| >1.05 | 222 | 109 | 53 | 384 | 0.8 (0.6 to 1.0) | 1.8 (1.2 to 2.8) | 155 | 248 | 71 | 474 | 3.6 (2.1 to 6.1) | 4.3 (1.9 to 10.0) | ||
The estimates were obtained by multinomial logistic regression, stratified by BMI and adjusted for age at examination, educational level, smoking, time since last meal and oral contraceptive use.
Number of women: with ≥2 children (n, reference group), nulliparous women (na), one-child mothers (nb) and total number of women within the category (N).
*Quintiles calculated on a total sample prior to pregnancy.
†Missing data within lipids on 16 cases of LDL, 2 cases of TG and 2 cases of TG:HDL-c ratio.
BMI, body mass index; LDL, low-density lipoprotein; TG, triglyceride; TG:HDL, TG to high-density lipoprotein ratio.