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. Author manuscript; available in PMC: 2018 Jul 12.
Published in final edited form as: Cell Transplant. 2015 Mar 6;25(1):35–53. doi: 10.3727/096368915X687697

Figure 5.

Figure 5

Preconditioning adult CDCs with PHDIs. P2 CDCs at 70% to 80% confluency were treated with (A) DMOG and (B) BIC at varying concentrations (n = 4). The percentage of dead cells was determined after 24 h and 4 days of treatment. *p < 0.05 versus nontreated control. (C) Western blot analysis of HIF-1α (left panel) and GLUT-1 (right panel) protein levels in 70% to 80% confluent P2 CDCs treated with (i) DMOG and (ii) BIC with a range of concentrations for 24 h or 4 days (n = 3). Protein levels were expressed in arbitrary units relative to cells treated with control at 24 h. *p < 0.05 versus control at 24 h; #p < 0.05 versus corresponding concentration at 24 h; $p < 0.05 between the two groups linked with arrow. (D) PHDI-treated CDC proliferation over 4 days of treatment with 1 mM DMOG and 30 µM BIC (n = 4). Both PHDIs increased cell proliferation for the initial 24 h (p = 0.07 for DMOG, p < 0.05 for BIC nontreated control).

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