Table 2. Significant regulation of TH-responding gene signature.
| Gene symbol | Probe ID | Thyroid tissue (conv.) |
Follicular cells (deconv.) | C-cells (deconv.) |
|---|---|---|---|---|
| log2 ratio; fold change (adjusted p-value) | ||||
| Atp2a1 | ILMN_2666864 | 5.3; 41 (0.0000) | 7.8; 223 (0.0000) | 11; 1552 (0.0000) |
| Camkk1 | ILMN_1242310 | -2.2; -4.6 (0.0045) | ||
| Camkk2 | ILMN_1256263 | -3.9; -15 (0.0001) | ||
| Ccnd1 | ILMN_1221503 | -0.92; -1.9 (0.0019) | ||
| ILMN_2601471 | -0.91; -1.9 (0.0002) | |||
| Cd44 | ILMN_3114585 | -0.69; -1.6 (0.0001) | -3.2; -9.2 (0.0000) | |
| ILMN_2754990 | -5.6; -49 (0.0000) | |||
| Cdkn1a† | ILMN_2846775 | -3.4; -11 (0.0001) | ||
| Egf | ILMN_2684104 | -4.9; -31 (0.0000) | -5.3; -39 (0.0000) | |
| Egfr | ILMN_3128725 | -4.9; -30 (0.0095) | ||
| Fos† | ILMN_2750515 | 5.0; 32 (0.0001) | ||
| Hnrnph3 (Hnrph3) | ILMN_2958912 | 5.7; 52 (0.0000) | ||
| Lmo2 | ILMN_2767605 | -1.2; -2.3 (0.0000) | ||
| Mbp | ILMN_3081854 | -2.9; -7.5 (0.0037) | ||
| Pck1 | ILMN_1213632 | 1.2; 2.3 (0.0001) | ||
| Pfkp | ILMN_2673233 | 5.7; 52 (0.0000) | ||
| Pik3c2a | ILMN_1252098 | -2.5; -5.7 (0.0087) | ||
| Prkag2 | ILMN_3161626 | 0.80; 1.7 (0.0002) | ||
| Prkca | ILMN_1217890 | -1.9; -3.7 (0.0092) | ||
| Rcan2 | ILMN_3033007 | -5.0;-32 (0.0000) | ||
| Slc16a6 | ILMN_1258950 | -0.91; -1.9 (0.0005) | ||
| Slc2a1 | ILMN_1258159 | -0.94; -1.9 (0.0007) | ||
| Sms | ILMN_1232323 | -2.3; -4.9 (0.0003) | ||
| Vldlr | ILMN_1218264 | 1.1; 2.2 (0.0000) | ||
| ILMN_2515601 | 1.1; 2.2 (0.0000) | |||
| ILMN_2796472 | 1.1; 2.2 (0.0000) | |||
†Note that Ccnd1, Cdkn1a and Fos are reported as both IR-associated and TH-responding in the literature. Results of transcript regulation of respective signature genes for thyroid tissue adapted from Langen et al. [16]. Conv., convoluted data; deconv., deconvolved data. Adjusted p-values given as 0.0000 designate values below 10−5, i.e. values below the Nexus Expression limit.