Fig 4. SAMBADENA HP of ¹³C HEP and subsequent ¹³C-MRI in vivo.

¹³C-MRI (a), ¹H-MRI (b), ¹H-¹³C co-registration (c) and schematic view (d) of a living mouse after the injection of ~80 mM HEP in 150 μl H₂O (P ≈ 4% at the time of MRI). Strong ¹³C signal with an SNR of 35 was detected (a). A T₂-weighted ¹H-MRI (b) was acquired and co-registered with the ¹³C-image (c). The signal may be attributed to the vena cava, aorta and femoral arteries as shown schematically in (d). The isocenter of the magnet was the center of the images. Note that the tracer did not leave the magnet. [d): adapted with permission from www.biologycorner.com published under CC BY-NC-SA 4.0 license].