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. 2018 Jul 12;13(7):e0200472. doi: 10.1371/journal.pone.0200472

Fig 1. Neuroendocrine transdifferentiation of LNCaP cells through androgen deprivation.

Fig 1

(A) LNCaP cells were cultivated in media with charcoal-stripped FCS (CS-FCS) or control FCS for 14 days. Transdifferentiated cells show dendrite like cell processes indicated by black arrows. (B) Successful transdifferentiation was validated through time course expression analysis of AR, PSA, NSE, NTS and TUBB3 in transdifferentiated LNCaP cells compared to untreated cells during androgen deprivation for 14 days by RT-PCR. Beta-actin and GAPDH served as endogenous controls.

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