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. 2018 Jul 12;13(7):e0200268. doi: 10.1371/journal.pone.0200268

Fig 5. Reeler-like phenotype observed in apoer2/vldlr doube knockout mice (DKO) at P20.

Fig 5

(A) Normal formation of the two lateral wings (arrows) of the dorsal raphe nuclei in wild type. (B) In DKO mice, the lateral wings of the dorsal raphe nuclei do not develop properly. In turn, more 5-HT neurons accumulate in the midline (arrowheads) as compared to wild type. (C) Normal development of the paramedian raphe on both sides of the median raphe in a wild type section at P20 (see boxed area shown at higher magnification in E). (D) Striking loss of the paramedian raphe in a DKO mouse at P20 as compared to an aged-matched wild type mouse (see boxed area shown at higher magnification in F). Scale bar A, B, E, and F: 100μm; C, D: 300μm.