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. 2018 Jul 12;13(7):e0200474. doi: 10.1371/journal.pone.0200474

Fig 8. AZM treatment reduces scar size and enhances angiogenesis after myocardial injury.

Fig 8

Representative Masson's trichrome staining at 30 days after myocardial injury in vehicle- and AZM-treated groups (Panel A). Quantitative analysis of scars as percentage of LV area shows significant reduction in AZM group relative to the control group (Panel B) (vehicle-treated, n = 15 vs. AZM-treated, n = 12, **P<0.01 compared to vehicle controls). Representative isolectin staining (Green) for capillary density in the peri-infarct region in AZM- and vehicle-treated animals demonstrates higher capillary density in AZM group compared to control (Panel C). Quantitative analysis of capillary density confirms the higher angiogenesis rate and capillary density in AZM-treated group (Panel D) (n = 4 animals/group, **P<0.01 compared to vehicle controls). Scale bars represent 50 μm. Data presented as mean ± SEM. AZM, azithromycin; MI, acute myocardial infarction; LV, left ventricular.