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. 2018 Jul 12;13(7):e0200474. doi: 10.1371/journal.pone.0200474

Fig 9. AZM treatment improves chronic cardiac remodeling and survival post-MI.

Fig 9

30 day following MI, transthoracic echocardiography using M-Mode (Panel A) and 2D echocardiography was performed on AZM- and vehicle-treated animals to evaluate left ventricular function and remodeling parameters. Quantitative analyses demonstrate significant recovery in LV function as assessed by ejection fraction (LVEF) (Panel B) and fractional shortening (FS) (Panel C). Data also shows significant improvements in LV adverse remodeling parameters such as end-systolic diameter (LVESD) (Panel D) and end-diastolic diameter (LVEDD) (Panel E). Additionally, we observed significantly thicker infarct walls suggesting of enhanced recovery and regeneration (Panel F). Survival curves of AZM and vehicle-treated mice 30 days post-MI demonstrate a significant improvement in survival with AZM treatment (Panel G). (Echo data: vehicle-treated, n = 15 vs. AZM-treated, n = 12; survival data: vehicle-treated, n = 48 and AZM-treated, n = 53; *P<0.05, **P<0.01 and ****P<0.001 compared to vehicle control). Data presented as mean ± SEM. AZM, azithromycin; MI, acute myocardial infarction.