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. Author manuscript; available in PMC: 2018 Jul 12.
Published in final edited form as: Neuroreport. 2009 Nov 25;20(17):1534–1537. doi: 10.1097/WNR.0b013e328331f968

Table 1.

Age-related changes in serum and brain levels (mean ±standard error) of testosterone, DHT, and estrogen (E2) in male Brown Norway rats

Age of male rats
3 Months 13 Months 23 Months P value
Serum testosterone
 (ng/ml)		  2.9 ± 0.9  1.5 ± 0.4  1.1 ± 0.2 0.07
Serum DHT (pg/ml) 57.2 ± 10.1 50.0 ± 9.4 68.0 ± 10.1 0.45
Serum E2 (pg/ml)  5.0 ± 8.0 21.0 ± 8.7  7.6 ± 8.7 0.41
Brain testosterone
 (ng/g WT)		  2.1 ± 0.5  1.4 ± 0.5  1.3 ± 0.6 0.50
Brain DHT (ng/g WT) 0.65 ± 0.1 0.13 ± 0.1* 0.08 ± 0.1* 0.004
Brain E2 (pg/g WT) 79.6 ± 15.9 50.7 ± 15.9 27.7 ± 17.1 0.11

DHT, dihydrotestosterone; WT, wet tissue.

*

P<0.05 relative to 3 months.