Table 3: Simulated PK changes caused by nonlinear plasma and tissue protein binding.

				Change with Time
fuP	fuT	CLint	Vd	fuP	fuT	Vd	CL	ke	t1/2	Cp	Cu
Typical Nonlinear	Linear	Low	Low	↓	-	↓	↓	↓*	↑*	Concave*	Concave*
			High	↓	-	↓	↓	-*	-*	Convex*	Linear*
		High	Low	↓	-	↓	-	↑	↓	Convex	Sigmoidal
			High	↓	-	↓	-	↑	↓	Convex	Convex
Linear	Typical Nonlinear	Low	-	-	↓	↑	-	↓	↑	Concave	Concave
		High	-	-	↓	↑	-	↓	↑	Concave	Concave
Typical Nonlinear		Low	-	↓	↓	-*	↓	↓*	↑*	Concave*	Concave*
		High	-	↓	↓	-*	-	-*	-*	Linear*	Sigmoidal*

*During the simulations of øie and colleagues²¹ changes in influential parameters impacted subsequent parameters differently depending on the relative changes in other parameters. For those with an asterisks, simulated results are listed but theoretically under different conditions the results may differ.