. Author manuscript; available in PMC: 2018 Jul 12.

Published in final edited form as: J Thorac Cardiovasc Surg. 2015 Feb 7;149(5):1374–1381. doi: 10.1016/j.jtcvs.2014.10.128

TABLE 5.

Patterns of failure after extrapleural pneumonectomy and radiation therapy (with or without neoadjuvant or adjuvant chemotherapy) for malignant pleural mesothelioma from several institutions

	No. treated with EPP	No. treated with EPP and RT	Treatment	RT technique	% with recurrence	LR %	Isolated LR %	DR %
Current series	169	71^* (42%)	EPP, HIOC, CTX, RT	44% EPT, 30% IMRT, 11% other	75	39	15	53
Baldini and colleagues¹⁰	46^*	35 (76%)	EPP, CTX, RT	2D-RT	54	35	13	41
Gupta and colleagues¹⁹	86	78^* (91%)	EPP, RT	EPT	74	41	19	55
Buduhan and colleagues²²	46	38^* (83%)	CTX, EPP, RT	63% EBRT, 37% IMRT	63	32	18	45
Gomez and colleagues⁶	136	86^* (64%)	EPP, RT	IMRT	62	16	2	59
de Perrot and colleagues³	45	30^* (67%)	CTX, EPP, RT	IMRT 3D-CRT	53	17	17	37
Tonoli and colleagues²⁵	56	56^* (100%)	EPP, RT, CTX	89% IMRT 7% 3D-CRT 4% HT	30	9	9	23
Krug and colleagues⁴	57^*	40 (70%)	CTX, EPP, RT	EPT IMRT	40	19	14	26
Rea and colleagues²⁰	17^*	15 (88%)	CTX, EPP, RT	EPT	77	35	NS	65
Patel and colleagues²⁴	30^*	30^* (100%)	EPP, RT, CTX	IMRT	73	33	13	60
van Sandick and colleagues²³	15^*	15^* (100%)	EPP, RT	IMRT	73	33	9	67
Van Schil and colleagues⁵	42	37^* (88%)	CTX, EPP, RT	3D-CRT	NS	16	NS	27

EPP, Extrapleural pneumonectomy; RT, radiation therapy; LR, local recurrence; DR, distant recurrence (including abdomen and CHT); HIOC, heated intraoperative chemo-therapy; CTX, chemotherapy; IMRT, intensity-modulated radiation therapy; 2D-RT, 2-dimensional radiation therapy; EPT, electron-photon technique; EBRT, external beam radiation therapy; 3D-CRT, 3-dimensional conformal radiation therapy; HT, helical tomotherapy; NS, not stated.

Patient cohort for reported recurrence results.