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. Author manuscript; available in PMC: 2019 Jul 11.
Published in final edited form as: Cell Host Microbe. 2018 Jun 21;24(1):97–108.e4. doi: 10.1016/j.chom.2018.05.009

Fig. 2. Effects of vitamin E and cell death inhibitors on sepsis in mice.

Fig. 2

(A) Analysis of animal survival in mice with or without repeated intraperitoneal administration of vitamin E (500 mg/kg) at three, 24, 48, and 72 hours after CLP (22-gauge needle)-induced sepsis (n=5–10 mice/group; *, P<0.05, Kaplan-Meier survival analysis). (B) In parallel, serum levels of MDA, 4-HNE, CK, BUN, and ALT were assayed at 72 hours after CLP (n=5 mice/group; *, P<0.05, ANOVA LSD test). Data are presented as median value (black line), interquartile range (box), and minimum and maximum of all data (black line). (C) Analysis of animal survival in mice with or without repeated intraperitoneal administration of Z-VAD-FMK (“ZVF”, 5 mg/kg), wedelolactone (“Wed”, 20 mg/kg), ferrostatin-1 (“Fer”, 10 mg/kg), or necrostatin-1 (“Nec”, 5 mg/kg) at three, 24, 48, and 72 hours after CLP (22-gauge needle)-induced sepsis (n=10 mice/group; *, P<0.05, Kaplan-Meier survival analysis). (D) In parallel, serum levels of IL-1β, IL-18, HMGB1, IL-6, IL-10, IL-17, and IL-12 were assayed at 72 hours after CLP (n=5 mice/group; *, P<0.05, ANOVA LSD test). Data are presented as median value (black line), interquartile range (box), and minimum and maximum of all data (black line).