(A) Analysis of animal survival in mice with or without repeated intraperitoneal
administration of U73122 (30 mg/kg) at three, 24, 48, and 72 hours after CLP
(22-gauge needle)-induced sepsis (n=10–20 mice/group; *,
P<0.05, Kaplan-Meier survival analysis).
Gpx4Mye−/− mice
data was the same control as Fig. 1H
(middle-grade sepsis). (B) In parallel, quantitation of serum CK, BUN, and ALT
in middle grade septic mice at 72 hours (n=5–8 mice/group;
*, P<0.05, ANOVA LSD test). Data
are presented as median value (black line), interquartile range (box), and
minimum and maximum of all data (black line).