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. Author manuscript; available in PMC: 2019 Jul 11.
Published in final edited form as: Cell Host Microbe. 2018 Jun 21;24(1):97–108.e4. doi: 10.1016/j.chom.2018.05.009

Fig. 7. PLC activation contributes to GSDMD-mediated septic death.

Fig. 7

(A) Analysis of animal survival in mice with or without repeated intraperitoneal administration of U73122 (30 mg/kg) at three, 24, 48, and 72 hours after CLP (22-gauge needle)-induced sepsis (n=10–20 mice/group; *, P<0.05, Kaplan-Meier survival analysis). Gpx4Mye−/− mice data was the same control as Fig. 1H (middle-grade sepsis). (B) In parallel, quantitation of serum CK, BUN, and ALT in middle grade septic mice at 72 hours (n=5–8 mice/group; *, P<0.05, ANOVA LSD test). Data are presented as median value (black line), interquartile range (box), and minimum and maximum of all data (black line).