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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Hypertension. 2018 Jun 18;72(2):361–369. doi: 10.1161/HYPERTENSIONAHA.118.11070

Fig. 4. BK2R mediates BK-induced inhibition of the basolateral 40 pS K+ channels in the DCT.

Fig. 4

A single channel recording demonstrates the effect of 10 μM BK on the basolateral K+ channels in the DCT in the presence of 1 μM HOE (BK2R antagonist) (A) or in the presence of 1μM Lys-(des-Arg9, Leu8)-bradykinin (BK1R antagonist) (C). The holding potential was 0 mV and the channel closed level is indicated by a dotted line and “C”. (B) Bar graph summarizes the results of experiments in which the effects of HOE140 (1μM), BK (10 μM)+HOE140, BK1R antagonist (1μM) and BK+BK1R antagonist on the basolateral 40 pS K channel were examined (n=6).