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. Author manuscript; available in PMC: 2018 Jul 13.
Published in final edited form as: J Med Chem. 2018 Jun 25;61(13):5733–5750. doi: 10.1021/acs.jmedchem.8b00777

Figure 8.

Figure 8

In vivo efficacy of (A) 1 and (B) 12 in a mouse model of acute TB. Mice were dosed with either drug at 100 mg/kg (po) for 6 days per week, × 4 weeks. A similar dosing schedule applied to isoniazid (INH) at 25 mg/kg. CFU analysis of lung and spleen tissues were carried out on treated mice and drug-free (DF) infected mice at Day 14 (start of treatment, Early Control) and Day 42 (end of treatment, Late Control). Statistical analysis was by One-way ANOVA, multi comparison, Bonferroni post test, n=4/5 (4/5 mice per group); **p<0.01; ****p<0.0001. Figure depicts individual data points, means and SD. Numbers above groups reflect difference as compared to the drug free (DF) control at day 42 (Late Control).