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. Author manuscript; available in PMC: 2018 Jul 13.
Published in final edited form as: J Med Chem. 2018 Jun 25;61(13):5733–5750. doi: 10.1021/acs.jmedchem.8b00777

Table 5.

Antimycobacterial profiles of Compounds 1, 10-14

No Ra Mtb H37Rv (μM) M.bovis BCG (μM) mic50 (μm) (M.bovis BCG) in 7H9 Mediab
MIC50b MIC90b MBC99.9c MBC99.9c Standard Mediumd Without Glycerol With 10% FBS
1 graphic file with name nihms976318t92.jpg 1.2 2.3 ND 3-6 1.5 1.6 1.1
10 graphic file with name nihms976318t93.jpg 0.6 0.95 ND 0.8-1.6 0.36 0.37 0.32
11 graphic file with name nihms976318t94.jpg 0.7 1.1 ND 0.8-1.6 0.29 0.27 0.28
12 graphic file with name nihms976318t95.jpg 0.44 0.76 3.2 0.8-1.6 0.30 0.35 0.33
13 graphic file with name nihms976318t96.jpg 0.5 0.8 3.2 0.4-1.6 0.26 0.41 0.6
14 graphic file with name nihms976318t97.jpg 0.5 0.78 ND 0.8-1.6 0.28 0.43 0.48
a

Refer to general structure given in Table 1

b

Average of 2 or more separate determinations.

c

MBC99.9: Minimum bactericidal concentration required to kill 99.9% of bacteria. Average of 2 or more separate determinations. MBC99.9 of 1, 10, 11, 14 on Mtb H37Rv were not determined (ND).

d

Standard 7H9 medium contains glycerol and does not contain FBS