Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Snapshot PK profiles of 1, 12 and 13a
| 1 | 12 | 13 | |
|---|---|---|---|
| Peak plasma concentration (ng/mL) | 42.0 | 64.8 | 60.6 |
| Area under the concentration time curve (AUC) (ng.h/mL) | 173 | 282 | 224 |
| Plasma concentration at 5 h (ng/mL) | 33.0 | 58.5 | 55.2 |
| Lung concentration at 5 h (ng/g) | 467.5 | 1408 | 1596 |
| Ratio of lung concentration to plasma concentration (Lung\Plasma) at 5 h | 14.2 | 24.1 | 28.9 |
1, 12 and 13 were administered at 25 mg/kg (PO) to CD1 mice (n=2 for each compound).
