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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Hypertension. 2018 Jun 4;72(2):370–380. doi: 10.1161/HYPERTENSIONAHA.118.11239

Figure 5. EV-YF1 and CDC-exo treatment decrease Ang II-induced kidney inflammation and fibrosis.

Figure 5

A-C, gene expression of CD68 in A, Il16 in B and Il1b in C in kidney tissue from mice that received subcutaneous infusion of Ang II for 28 days of saline or Ang II treated with saline, EV-YF1 or CDC-exo, as determined by qPCR. Graphs depict the mean ± SEM; n = 5 animals/group. D, micrographs (magnification: ×20) showing representative tubulointerstitial fibrosis (arrows) in kidney sections stained with Masson’s trichrome. E, Quantitative measurements of tubulointerstitial fibrosis within kidney sections. Data are means ± SEM; n = 5 animals/group. Scale bars = 70 μm. Groups were compared using 1-way ANOVA followed by Tukey’s multiple comparisons test; *P < 0.05, **P < 0.01, ***P < 0.001.