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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Semin Cell Dev Biol. 2018 Jan 12;82:79–85. doi: 10.1016/j.semcdb.2018.01.002

Figure 1. Peptidase clan CD dendrogram illustrating evolutionary relationships of human caspases and their homologs.

Figure 1

Apoptotic caspases are featured in green hues, inflammatory caspases in red, and the remaining four human members of peptidase clan CD are in blue. Caspases-2 and −14 are uncolored and unassigned, as they have primary roles unassociated with apoptosis or inflammation. Pseudoproteases, FLIP and caspase-12, are proteins with the characteristic fold but mutations in their catalytic machinery render them proteolytically incompetent.