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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Semin Cell Dev Biol. 2018 Jan 12;82:79–85. doi: 10.1016/j.semcdb.2018.01.002

Table 1.

Human clan CD proteases, their biological functions, primary specificity, and activation mechanisms.

Clan CD member Biological Role Primary specificity Activation mechanism
Caspase-1, 4, 5 Inflammatory caspases Asp No consensus – probably dimerization
Caspase-12 Putative pseudocaspase - inflammation -
Caspase-9 Intrinsic pathway apical caspase Asp Dimerization
Caspase-8, 10 Extrinsic pathway apical caspases Asp Dimerization
FLIP Pseudocaspase – extrinsic pathway -
Caspase-3, 6, 7 Apoptotic effector (executioner) caspases Asp Intra-domain cleavage
Caspase-2 “Multifunctional” caspase Asp No consensus
Caspase-14 Keratinocyte differentiation Asp Intra-domain cleavage
MALT1 B, T-cell activation via NFkB Arg Dimerization
Legumain Antigen presentation, lysosomal protein degradation Asn Removal of N-domain
Separase Sister chromatid separation during anaphase Arg Removal of blocking inhibitor
PIGK C-terminal processing of proteins destined for GPI anchor addition Asn/Ser* Unknown