Fig. 2.

a Nociceptive thermal threshold (tail flick test) and b orofacial mechanical allodynia (Von Frey test) following chronic and intermittent NTG administration and chronic topiramate (TOP) treatment in rats. CT = NTG vehicle + TOP vehicle (n = 13); NTG = NTG + TOP vehicle (n = 12); TOP = NTG vehicle + Topiramate (n = 8); NTG + TOP = NTG + Topiramate (n = 8). Data are expressed as mean + SEM; two-way ANOVA followed by Bonferroni post hoc tests, F = 6.019 for tail flick test; F = 4.091 for Von Frey test. *p < 0.05 vs NTG baseline; °p < 0.05 vs NTG + TOP baseline; #p < 0.05 vs CT and TOP 1 day 10; §p < 0.05 vs NTG day 10