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CGRP and c-Fos mRNA expression in areas involved in trigeminal nociception, following chronic and intermittent NTG administration in rat. CT = NTG vehicle + TOP vehicle (n = 10); NTG = NTG + TOP vehicle (n = 9); TOP = NTG vehicle + Topiramate (n = 5); NTG + TOP = NTG + Topiramate (n = 5). Data are expressed as mean + SEM. One way ANOVA followed by Newman-Keuls Multiple Comparison Test **p < 0.01 and ***p < 0.001 vs CT and TOP; °°°p < 0.001 vs NTG
