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. 2018 Jul 12;8:10500. doi: 10.1038/s41598-018-28861-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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RGN-259 reduced detachment of corneal epithelial cells comparable to that of DQS. (A) The sections are stained with hematoxylin-eosin. The arrows indicate the detached corneal epithelial cells. Scale bar = 100 μm. (B) The number of detached corneal epithelial cell. ^*P < 0.05 vs. the corresponding value in the baseline desiccation stressed group. ^#P < 0.05 vs. the value in the vehicle-treated group. ^§P < 0.05 vs. the value in the RGN-259, 2 times per day group. ^†P < 0.05 vs. the value in the RGN-259, 4 times per day group. ^¶P < 0.05 vs. the value in the CsA group. ^‡P < 0.05 vs. the value in the DQS group. ^&P < 0.05 vs. the value in the LFA group.