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. 2018 Jul 12;8:10520. doi: 10.1038/s41598-018-28484-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Principal component (PC) analysis of the data from four cytokines (VEGF-A, MCP-1, bFGF and GM-CSF). Neovascular age-related macular degeneration (nAMD; green), pachychoroid neovasculopathy (PNV; red) and control (blue) are plotted in a space defined by PCs 1 and 2, which are the two best axes representing the entire dataset. In the PC-1 axis, the control group is well separated from the other two groups. PNV and nAMD are distinguished by the PC-2 axis. The results of PC analysis indicate that the three pathological conditions form clusters and can be distinguished by four types of cytokines. VEGF-A = vascular endothelial growth factor A; MCP-1 = monocyte chemoattractant protein 1; bFGF = basic fibroblast growth factor; GM-CSF = granulocyte macrophage colony-stimulating factor.