Table 2.
Levels of Ten Cytokines in the AH among the Three Groups.
| Pachychoroid neovasculopathy |
Neovascular AMD |
Control | ||
|---|---|---|---|---|
| n = 18 | n = 18 | n = 11 | p-value* | |
| IL-1ra, pg/ml | 97.13 (31.71–204.12) | 93.52 (11.69–238.09) | 231.11 (120.64–295.89) | 0.16 |
| IL-6, pg/ml | 2.96 (2.10–10.80) | 6.90 (3.62–12.31) | 3.40 (2.46–3.89) | 0.10 |
| IL-8, pg/ml | 5.53 (3.25–6.81) | 6.44 (4.84–9.78) | 6.80 (4.32–8.33) | 0.19 |
| MCP-1, pg/ml | 190.01 (155.43–247.69) | 242.24 (139.99–255.59) | 267.56 (245.73–321.87) | 0.01 |
| MIP-1β, pg/ml | 15.93 (11.65–20.20) | 15.92 (14.46–25.64) | 15.13 (9.16–27.15) | 0.72 |
| IP-10, pg/ml | 152.98 (74.51–231.74) | 183.60 (147.90–280.66) | 146.15 (87.31–195.22) | 0.09 |
| bFGF, pg/ml | 10.75 (6.87–18.28) | 16.95 (10.23–23.47) | 29.61 (17.88–37.51) | <0.01 |
| GM-CSF, pg/ml | 46.19 (27.05–61.31) | 56.61 (30.69–76.18) | 136.87 (96.37–183.51) | <0.01 |
| VEGF-A, pg/ml | 153.78 (103.76–178.14) | 203.21 (154.88–277.66) | 124.53 (101.44–173.02) | <0.01 |
| PlGF, pg/ml | 4.30 (2.67–5.81) | 4.63 (3.61–6.77) | 4.08 (2.29–5.62) | 0.36 |
Values are the median (interquartile range).
P < 0.05 was considered significant (bold).
*Kruskal-Wallis test.
AMD = age-related macular degeneration; IL-1ra = interleukin 1 receptor antagonist; IL = interleukin; MCP-1 = monocyte chemoattractant protein 1; MIP-1β = macrophage inflammatory protein 1β; IP-10 = interferon-γ-induced protein 10; bFGF = basic fibroblast growth factor; GM-CSF = granulocyte macrophage colony-stimulating factor; VEGF-A = vascular endothelial growth factor A; PlGF = placental growth factor. Other cytokines were below the detection limit.