Table 3.
Spearman’s Rank Correlation Coefficient for Ten Cytokines in Patients with Pachychoroid Neovasculopathy (a) and Neovascular Age-related Macular Degeneration (b).
| IL-1ra | IL-6 | IL-8 | MCP-1 | MIP-1β | IP-10 | bFGF | GM-CSF | VEGF-A | |
|---|---|---|---|---|---|---|---|---|---|
| Pachychoroid neovasculopathy | |||||||||
| IL-6 | −0.03 | 1 | |||||||
| IL-8 | 0.11 | 0.34 | 1 | ||||||
| MCP-1 | 0.38 | 0.4 | 0.38 | 1 | |||||
| MIP-1β | −0.07 | 0.23 | 0.65 † | 0.39 | 1 | ||||
| IP-10 | 0.54* | 0.18 | 0.2 | 0.35 | 0.22 | 1 | |||
| bFGF | −0.53* | 0.23 | 0.41 | −0.09 | 0.35 | −0.2 | 1 | ||
| GM-CSF | −0.58* | −0.04 | 0.03 | −0.1 | 0.15 | −0.44 | 0.58* | 1 | |
| VEGF-A | 0.19 | 0.38 | 0.35 | 0.13 | 0.25 | 0.59* | 0.26 | −0.22 | 1 |
| PlGF | 0.26 | 0.37 | 0.43 | 0.01 | 0.12 | 0.44 | 0.23 | −0.50* | 0.58* |
| Neovascular age-related macular degeneration | |||||||||
| IL-6 | −0.09 | 1 | |||||||
| IL-8 | −0.08 | 0.78 ‡ | 1 | ||||||
| MCP-1 | −0.14 | 0.68 † | 0.68 † | 1 | |||||
| MIP-1β | −0.21 | 0.49* | 0.32 | 0.53* | 1 | ||||
| IP-10 | −0.31 | 0.2 | 0.12 | 0.18 | 0.42 | 1 | |||
| bFGF | 0.4 | 0.04 | 0.14 | 0.1 | −0.41 | 0.12 | 1 | ||
| GM-CSF | 0.38 | −0.15 | 0.01 | 0.05 | −0.49* | −0.03 | 0.90 ‡ | 1 | |
| VEGF-A | <0.01 | 0.14 | 0.25 | −0.1 | −0.28 | −0.01 | 0.46 | 0.32 | 1 |
| PlGF | 0.19 | 0.16 | 0.21 | −0.19 | −0.2 | −0.34 | 0.14 | 0.13 | 0.17 |
*P < 0.05, †p < 0.01, ‡p < 0.001, p < 0.05 were considered significant (bold).
IL-1ra = interleukin 1 receptor antagonist; IL = interleukin; MCP-1 = monocyte chemoattractant protein 1; MIP-1β = macrophage inflammatory protein 1β; IP-10 = interferon-γ-induced protein 10; bFGF = basic fibroblast growth factor; GM-CSF = granulocyte macrophage colony-stimulating factor; VEGF-A = vascular endothelial growth factor A; PlGF = placental growth factor. Other cytokines were below the detection limit.