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. 2018 Jul 12;8:10512. doi: 10.1038/s41598-018-28358-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Conformation exchange in μs-ms timescale in Fag s 1 major cavity. (a) Difference between R_2eff, ΔR_2eff obtained using the lowest and the highest CPMG frequency (66.7 and 1000 Hz) as a function of Fag s 1 residues number. Residues showing ΔR_2eff higher than 5 Hz are colored in red. (b) Fag s 1 and Bet v 1 cavity mapped using 3V as described in Material and Methods. Residues in conformation exchange are colored in red and the side chains that point towards the cavity are also shown. Residues with broadened resonances are colored in yellow (c) Zoom of some regions of Fag s 1 cavity showing crucial side chains forming specific bottlenecks; (f) Reaction coordinate diagram at 298 K.