Table 3.
Commonly methylated genes of seven aldehydes exposed-A549 cell compared to vehicle control with 3.0-fold change and p-value < 0.05.
| Gene Symbol | Gene name | Methylation degree (Fold-change) | ||||||
|---|---|---|---|---|---|---|---|---|
| C3 | C4 | C5 | C6 | C7 | C8 | C9 | ||
| ZFHX2 | zinc finger homeobox protein 2 | 12.98 | 3.32 | 10.00 | 8.15 | 3.33 | 11.36 | 13.54 |
| TTTY5 | testis-specific transcript, Y-linked 5 | 55.06 | 59.56 | 334.00 | 95.77 | 17.98 | 10.80 | 80.09 |
| CCDC21;CEP85 | centrosomal protein 85 | 66.14 | 49.39 | 52.05 | 164.01 | 134.69 | 129.86 | 86.00 |
| GJA9-MYCBP | GJA9-MYCBP readthrough | 8.75 | 3.55 | 6.45 | 6.10 | 3.69 | 8.61 | 12.25 |
| PRKACB | protein kinase cAMP-activated catalytic subunit beta | 823.47 | 78.87 | 1169.04 | 362.87 | 560.59 | 1057.51 | 1139.15 |
| LPPR5 | lipid phosphate phosphatase-related protein type 5 isoform 2 | 7.93 | 5.74 | 6.59 | 7.30 | 8.36 | 7.68 | 7.68 |
| TDRKH | tudor and KH domain containing | 6.99 | 10.40 | 7.49 | 7.88 | 6.52 | 9.72 | 13.72 |
| OR10Z1 | olfactory receptor family 10 subfamily Z member 1 | 3.17 | 3.88 | 3.62 | 4.89 | 3.68 | 5.29 | 6.37 |
| NUF2 | NUF2, NDC80 kinetochore complex component | 8.99 | 27.81 | 37.15 | 15.14 | 4.05 | 5.39 | 6.90 |
| KCNF1 | potassium voltage-gated channel modifier subfamily F member 1 | 10.08 | 6.90 | 9.53 | 12.95 | 11.10 | 5.69 | 7.97 |
| C2orf61; STPG4 | sperm-tail PG-rich repeat containing 4 | 9.47 | 5.94 | 8.98 | 6.75 | 4.32 | 5.60 | 5.89 |
| BMP10 | bone morphogenetic protein 10 | 6.25 | 5.38 | 12.21 | 5.50 | 4.86 | 3.78 | 18.05 |
| REG1A | regenerating family member 1 alpha | 3.97 | 3.70 | 3.82 | 4.09 | 3.79 | 3.34 | 4.05 |
| MIR128-1 | microRNA 128-1 | 6.73 | 6.26 | 6.47 | 6.92 | 6.42 | 5.66 | 6.27 |
| UBXN4 | UBX domain protein 4 | 5.16 | 3.73 | 4.29 | 4.75 | 5.44 | 5.00 | 5.00 |
| WDR75 | WD repeat domain 75 | 6.02 | 5.01 | 6.58 | 6.02 | 6.12 | 14.02 | 7.04 |
| THUMPD3 | THUMP domain containing 3 | 5.45 | 9.95 | 5.95 | 5.45 | 5.54 | 5.78 | 3.27 |
| COX17 | COX17,cytochrome c oxidase copper chaperone | 22.46 | 18.67 | 24.53 | 22.46 | 22.82 | 15.61 | 28.73 |
| MFN1 | mitofusin 1 | 12.89 | 13.22 | 10.36 | 3.21 | 4.97 | 3.23 | 27.85 |
| NFXL1 | nuclear transcription factor, X-box binding like 1 | 16.26 | 4.96 | 8.71 | 7.16 | 11.07 | 7.78 | 5.77 |
| UGT2B10 | UDP glucuronosyltransferase family 2 member B10 | 9.04 | 8.45 | 13.47 | 3.98 | 6.16 | 11.61 | 12.51 |
| IGJ;JCHAIN | joining chain of multimeric IgA and IgM | 10.61 | 9.91 | 15.07 | 4.68 | 7.22 | 13.63 | 14.68 |
| HSD17B11 | hydroxysteroid 17-beta dehydrogenase 11 | 13.20 | 8.61 | 10.78 | 5.08 | 4.48 | 6.00 | 7.62 |
| SNCA | synuclein alpha | 12.42 | 11.60 | 11.19 | 5.47 | 8.45 | 15.95 | 17.18 |
| MIR583 | microRNA 583 | 15.37 | 18.05 | 12.78 | 14.15 | 16.21 | 5.69 | 14.89 |
| PCDHA9 | protocadherin alpha 9 | 300.99 | 40.15 | 5.39 | 76.53 | 254.52 | 56.58 | 64.89 |
| PCDHA10 | protocadherin alpha 10 | 105.50 | 98.53 | 149.77 | 46.49 | 229.99 | 135.49 | 145.95 |
| PHACTR1 | phosphatase and actin regulator 1 | 21.89 | 16.73 | 9.00 | 6.72 | 5.74 | 15.07 | 8.65 |
| HIST1H2BE | histone cluster 1 H2B family member e | 42.08 | 21.83 | 91.80 | 60.34 | 13.59 | 3.23 | 41.49 |
| TRIM27 | tripartite motif containing 27 | 3.50 | 13.33 | 47.39 | 7.21 | 9.71 | 6.19 | 12.52 |
| MRPS18A | mitochondrial ribosomal protein S18A | 292.96 | 127.71 | 246.55 | 239.77 | 219.35 | 91.89 | 370.17 |
| NMBR | neuromedin B receptor | 15.41 | 14.39 | 21.87 | 6.79 | 10.49 | 17.90 | 21.32 |
| LHFPL3 | lipoma HMGIC fusion partner-like 3 | 27.40 | 51.13 | 17.34 | 61.21 | 16.23 | 25.98 | 19.18 |
| PEX2 | peroxisomal biogenesis factor 2 | 101.62 | 124.05 | 115.75 | 156.58 | 117.68 | 169.28 | 109.65 |
| SPINK4 | serine peptidase inhibitor, Kazal type 4 | 13.95 | 12.61 | 6.96 | 10.09 | 7.85 | 5.19 | 8.88 |
| SLK | STE20 like kinase | 3.89 | 6.52 | 25.12 | 4.00 | 3.71 | 3.27 | 35.02 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha | 47.86 | 23.32 | 31.00 | 13.92 | 7.86 | 39.95 | 54.35 |
| CD163L1 | CD163 molecule like 1 | 8.33 | 16.73 | 25.48 | 3.28 | 7.12 | 9.91 | 14.92 |
| PRH1-PRR4 | PRH1-PRR4 readthrough | 8.49 | 9.50 | 24.44 | 3.64 | 8.42 | 6.82 | 16.24 |
| CCNA1 | cyclin A1 | 15.92 | 9.51 | 13.60 | 5.87 | 3.17 | 12.83 | 15.04 |
| CCNB1IP1 | cyclin B1 interacting protein 1 | 3.45 | 16.63 | 16.41 | 3.20 | 9.03 | 9.13 | 11.86 |
| C14orf104; DNAAF2 | dynein axonemal assembly factor 2 | 12.81 | 8.80 | 7.24 | 4.70 | 3.62 | 3.95 | 5.63 |
| C14orf166B; LRRC74A | leucine rich repeat containing 74 A | 4.87 | 3.74 | 6.05 | 4.08 | 4.38 | 3.21 | 4.33 |
| CSNK1A1P1 | casein kinase 1 alpha 1 pseudogene 1 | 11.74 | 5.67 | 8.68 | 5.57 | 7.31 | 14.50 | 6.04 |
| KIF7 | kinesin family member 7 | 11.73 | 14.32 | 3.39 | 18.08 | 6.31 | 10.21 | 12.66 |
| CHD3 | chromodomain helicase DNA binding protein 3 | 28.65 | 23.21 | 35.98 | 15.25 | 14.61 | 15.85 | 10.57 |
| PDE4A | phosphodiesterase 4A | 7.78 | 11.77 | 7.15 | 5.46 | 9.41 | 8.80 | 8.16 |
| ZNF525 | zinc finger protein 525 | 11.18 | 7.40 | 24.49 | 4.92 | 7.61 | 17.13 | 15.78 |
| C20orf191; NCOR1P1 | nuclear receptor corepressor 1 pseudogene 1 | 8.70 | 10.62 | 9.91 | 13.40 | 10.07 | 14.49 | 16.16 |
| MYT1 | myelin transcription factor 1 | 16.18 | 7.61 | 13.72 | 5.89 | 3.82 | 3.87 | 6.82 |
| AIRE | autoimmune regulator | 4.90 | 4.56 | 19.72 | 5.04 | 4.68 | 4.12 | 4.57 |
| ACOT9 | acyl-CoA thioesterase 9 | 15.50 | 12.40 | 20.91 | 10.68 | 28.30 | 24.78 | 18.05 |
| RPA4 | replication protein A4 | 245.44 | 74.49 | 183.14 | 399.31 | 242.59 | 133.71 | 106.36 |
| C9orf57 | chromosome 9 open reading frame 57 | 0.29 | 0.23 | 0.28 | 0.08 | 0.26 | 0.23 | 0.23 |