Table 4.
Association of the minor alleles of rs2281939 and rs2296966 with overall risk of DM and age of DM onset.
| SNP | Genotype (n) | Model | Overall risk of DM | Age of DM onset | |||
|---|---|---|---|---|---|---|---|
| O.R. (95% C.I.) | p-value (q-value)a | H.R. (95% C.I.) | p-value (q-value)a | p-value of Schoenfeld residuals test | |||
| rs2281939 | AA (869) | ADD | 0.82 (0.55, 1.20) | 0.30 | 0.93 (0.65, 1.35) | 0.71 | 0.87 |
| AG (256) | DOM | 0.78 (0.53, 1.15) | 0.21 | 0.88 (0.62, 1.26) | 0.50 | 0.71 | |
| GG (10) | REC | 1.73 (0.42, 7.22) | 0.45 | 4.31 (2.19, 8.47) | 0.000022 (0.0014) | 0.38 | |
| rs2296966 | CC (514) | ADD | 1.42 (1.14, 1.77) | 0.0020 (0.064) | 1.30 (1.07, 1.57) | 0.0079 (0.084) | 0.70 |
| CT (486) | DOM | 1.42 (1.04, 1.93) | 0.026 (0.17) | 1.36 (1.04, 1.78) | 0.024 (0.17) | 0.90 | |
| TT (135) | REC | 1.89 (1.20, 2.89) | 0.0032 (0.068) | 1.50 (1.04, 2.16) | 0.031 (0.17) | 0.36 | |
ADD, additive model; DOM, dominant model; REC, recessive model; O.R., odds ratio; C.I., confidence interval; H.R., hazard ratio.
aP-value < 0.05 was shown in bold and q-value was shown when p-value < 0.05.