Table 2.
Diagnostic performance of the Biochip system for the detection of drug resistance comparing to DST.
| Sensitivity for Rifampin | p value | Specificity for Rifampin | p value | Sensitivity for Isoniazid | p value | Specificity for Isoniazid | p value | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall | 86.08% | (272/316) | 97.70% | (1148/1175) | 79.36% | (323/407) | 98.71% | (1070/1084) | ||||
| Smear test | 0.9481 | 0.9997 | 0.9948 | 0.998 | ||||||||
| Scanty | 72.00% | (18/25) | 95.65% | (66/69) | 73.33% | (22/30) | 96.88% | (62/64) | ||||
| 1+ | 90.97% | (141/155) | 98.24% | (614/625) | 81.50% | (163/200) | 99.31% | (575/579) | ||||
| 2+ | 83.12% | (64/77) | 96.58% | (226/234) | 79.57% | (74/93) | 98.62% | (215/218) | ||||
| 3+ | 78.79% | (26/33) | 98.54% | (135/137) | 77.27% | (34/44) | 98.43% | (125/127) | ||||
| 4+ | 88.46% | (23/26) | 97.27% | (107/110) | 75.00% | (30/40) | 96.88% | (93/96) | ||||
| Patients | 1 | 0.8768 | 1 | 1 | ||||||||
| Treatment naïve | 92.76% | (141/152) | 97.51% | (626/642) | 78.97% | (169/214) | 98.45% | (572/581) | ||||
| Having been treated | 93.02% | (40/43) | 94.12% | (96/102) | 80.00% | (36/45) | 98.00% | (98/100) | ||||
| Type of sample | 0.9886 | 0.9924 | 0.9886 | 0.9924 | ||||||||
| Spot sputum | 80.23% | (69/86) | 99.30% | (284/286) | 80.23% | (69/86) | 99.30% | (284/286) | ||||
| Morning sputum | 79.54% | (241/303) | 98.57% | (757/768) | 79.54% | (241/303) | 98.57% | (757/768) | ||||
| Evening sputum | 84.62% | (11/13) | 96.00% | (24/25) | 84.62% | (11/13) | 96.00% | (24/25) | ||||
| Site | 0.0462 a | 0.9721 | 0.1122 | 0.9986 | ||||||||
| Hangzhou | 84.48% | (98/116) | 98.01% | (492/502) | 75.88% | (129/170) | 98.86% | (434/439) | ||||
| Jiaxing | 17.86% | (5/28) | 100.00% | (111/111) | 21.74% | (5/23) | 86.83% | (113/115) | ||||
| Jinhua | 94.74% | (18/19) | 98.65% | (146/148) | 100.00% | (21/24) | 97.95% | (143/143) | ||||
| Lingbo | 91.89% | (68/74) | 98.26% | (169/172 | 98.92% | (92/101) | 93.55% | (144/145) | ||||
| Lishui | 95.00% | (19/20) | 95.71% | (67/70) | 100.00% | (13/13) | 100.00% | (77/77) | ||||
| Taizhou | 100.00% | (20/20) | 98.41% | (62/63) | 92.00% | (17/17) | 100.00% | (64/66) | ||||
| Wenzhou | 89.80% | (44/49) | 92.66% | (101/109) | 77.97% | (46/59) | 95.96% | (95/99) | ||||
ap value is less than 0.05.
DST: drug-susceptibility testing.