Table 3.
Diagnostic performance of the Biochip system for the detection of multidrug-resistant tuberculosis (MDR-TB) comparing to DST.
| Sensitivity for MDR-TB | p value | Specificity for MDR-TB | p value | |||
|---|---|---|---|---|---|---|
| Overall | 78.01% | (220/282) | 98.86% | (1210/1224) | ||
| Smear test | 0.9476 | 0.9976 | ||||
| Scanty | 62.50% | (15/24) | 98.65% | (73/74) | ||
| 1+ | 81.43% | (114/140) | 99.07% | (638/644) | ||
| 2+ | 80.30% | (53/66) | 98.38% | (243/247) | ||
| 3+ | 75.86% | (22/29) | 100.00% | (143/143) | ||
| 4+ | 69.57% | (16/23) | 98.28% | (114/116) | ||
| Patients | 0.9798 | 0.9695 | ||||
| Treatment naïve | 80.45% | (107/133) | 98.81% | ((665/673) | ||
| Having been treated | 76.92% | (30/39) | 97.17% | (103/106) | ||
| Type of sample | 0.9775 | 0.9959 | ||||
| Spot sputum | 81.25% | (52/64) | 99.35% | (308/310) | ||
| Morning sputum | 78.20% | (165/211) | 98.85% | (858/868) | ||
| Evening sputum | 60.00% | (3/5) | 97.30% | (36/37) | ||
| Site | 0.0903 | 1 | ||||
| Hangzhou | 76.53% | (75/98) | 99.29% | (518/522) | ||
| Jiaxing | 18.18% | (4/22) | 100.00% | (120/120) | ||
| Jinhua | 87.50% | (14/16) | 100.00% | (151/151) | ||
| Lingbo | 90.28% | (65/72) | 98.28% | (171/174) | ||
| Lishui | 100.00% | (12/12) | 98.72% | (77/78) | ||
| Taizhou | 100.00% | (16/16) | 100.00% | (67/67) | ||
| Wenzhou | 73.91% | (34/46) | 94.64% | (106/112) | ||
MDR-TB: multidrug-resistant tuberculosis; DST: drug-susceptibility testing.