Table 3.
Multivariate regression analysis of RNFL loss in old and young age groups including autonomic nerve function indices (SDNN and LF/HF), arterial stiffness indices (CAVI and ABI) and laboratory findings.
| Old (≥50 yrs) | Young (<50 yrs) | |||||
|---|---|---|---|---|---|---|
| β | 95% CI | P Value | β | 95% CI | P Value | |
| Duration of DM | −0.010 | 0.891 to 1.100 | 0.857 | 0.128 | 0.990 to 1.305 | 0.069 |
| SDNN | 0.052 | 0.997 to 1.114 | 0.062 | −0.026 | 0.931 to 1.019 | 0.255 |
| LF/HF | 0.033 | 0.818 to 1.306 | 0.783 | −0.170 | 0.717 to 0.992 | 0.040 |
| HbA1c | 0.075 | 0.592 to 1.963 | 0.806 | 0.391 | 1.031 to 2.119 | 0.033 |
| eGFR | 0.007 | 0.969 to 1.047 | 0.723 | −0.001 | 0.969 to 1.030 | 0.967 |
| Total cholesterol | −0.134 | 0.720 to 1.064 | 0.180 | 0.039 | 0.959 to 1.127 | 0.345 |
| TG | 0.032 | 0.990 to 1.078 | 0.139 | −0.009 | 0.977 to 1.005 | 0.195 |
| HDL | 0.227 | 0.981 to 1.605 | 0.071 | −0.090 | 0.832 to 1.003 | 0.059 |
| LDL | 0.147 | 0.952 to 1.409 | 0.142 | −0.035 | 0.886 to 1.052 | 0.423 |
| CAVI | 0.222 | 0.550 to 2.835 | 0.596 | −0.061 | 0.541 to 1.636 | 0.828 |
| ABI | −11.057 | 0.000 to 0.046 | 0.007 | 4.258 | 0.191 to 26166.7 | 0.158 |
Enter mode was used for this logistic regression analysis.
CI: confidence interval.
SDNN: standard deviation of normal to normal intervals in heart rate variability; LF/HF: ratio of low-frequency power to high-frequency power in heart rate variability; HbA1c: glycosylated hemoglobin; eGFR: estimated glomerular filtration rate; TG: triglyceride; HDL: high-density lipoprotein; LDL: low-density lipoprotein; CAVI: cardio-ankle vascular index; ABI: ankle-brachial index.