Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jul 6;9:1583. doi: 10.3389/fimmu.2018.01583

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Mastoridis, Bertolino, Whitehouse, Dazzi, Sanchez-Fueyo and Martinez-Llordella.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Profiling of circulating exosomes for tissue-specific biomarker discovery and functional analysis (Application 2). (A) Small EVs (sEVs) from an HLA-B27-positive, HLA-B8-negative recipient were gated in G1 before and after receiving a liver allograft from an HLA-B8-positive, HLA-B27-negative donor. Bona fide CD63-positive exosomes were analyzed for their expression of donor and recipient HLA. Donor HLA-bearing exosomes become detectable in circulation after liver transplantation. (B) PD-L1 expression was analyzed in exosomes bearing either donor or recipient HLA and found higher in the former group post-transplantation. (C) Percentage of HLA-A3 positive sEVs were compared between genotypically confirmed HLA-A3+ (n = 3) and HLA-A3 negative (n = 3) individuals. (D) Percentage of donor-HLA + sEVs observed pre- and post-liver transplantation, in genotypically confirmed HLA-mismatched liver transplant recipients (n3). Data represented as mean ± SD. *P < 0.05.