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. 2018 Jul 6;9:1552. doi: 10.3389/fimmu.2018.01552

Figure 8.

Figure 8

Model of Nrf2-mediated roles in myeloid-derived suppressor cells (MDSCs) in sepsis. During infection and sepsis, Nrf2 is activated by reactive oxygen species (ROS) molecules or TLR pathways. Nrf2 induces cell cycle activation and enhances metabolic activity and thereby contributes to expansion of MDSCs in sepsis.