Figure 5:

Investigating the effect of exposure to patterning molecules during SOX2-mediated reprogramming. (A) Schematic detailing experimental outline for Study Eight. (B) Heat map depicting gene expression in iNPs as fold changes relative to control SOX2-iNPs cultured under standard reprogramming conditions. (C) Quantification of TUJ1+ and TUJ1+/TH+ cells in differentiated iNP cultures. Data are presented as mean ± SEM, n = 8 fields of view from one cell line (number of cells counted per condition ≥ 819). An ordinary one-way ANOVA revealed no effect of SHH/CHIR patterning on yields of TUJ1+ or TH+/TUJ1+ cells.