Table 1.

Studies reporting ICH rates in adult ECMO cohorts.

Study	Study design	Study length (years)	Patients (n)	% V-A ECMO	ICH (n)	ICH rate (%)	ICH characteristics
Fletcher-Sandersjöö et al. 23	Single-center, retrospective	10.8	253	36	54	21.3	76% intraparenchymal hemorrhage (IPH), 2% subdural hemorrhage (SDH), 22% subarachnoid hemorrhage (SAH)
Kasirajan et al. 14	Single-center, retrospective	5.0	74	100	14	18.9	ICH was defined as IPH and/or intraventricular hemorrhage
Klinzing et al. 15	Single-center, retrospective	6.0	74	27	8	10.8	25% >1 type, 88% IPH, 38% SAH
Lockie et al. 16	Single-center, retrospective	4.2	250	0	41	16.4	37% > 1 type, 20% large IPH, 39% petechial IPH, 56% SAH, 2% SDH
Lorusso et al. 18	Multicenter, ELSO data registry	22.0	4,522	100	80	1.8	NR
Lorusso et al. 17	Multicenter, ELSO data registry	24.0	4,988	0	181	3.6	NR
Luyt et al. 19	Single-center, retrospective	7.0	135	0	10	7.5	NR
Nasr and Rabinstein 4	Multicenter, Nationwide inpatient sample	11.0	8,397	NR	239	2.9	NR
Omar et al. 20	Single-center, retrospective	7.0	154	81	12	7.8	NR
Paden et al. 21	Multicenter, ELSO data registry	NR	NR	NR	NR	3.9	NR
Rastan et al. 24	Single-center, prospective	12.0	517	100	19	3.7	NR
Smedira et al. 22	Single-center, retrospective	7.5	202	100	13	6.4	NR

ICH, intracranial hemorrhage; IPH, intraparenchymal hemorrhage; SDH, subdural hemorrhage; SAH, subarachnoid hemorrhage; ECMO, extracorporeal membrane oxygenation; ELSO, Extracorporeal Life Support Organization; V-A, venoarterial; NR, not reported